What isAlzheimer’s?

Stem Cell Therapy for Alzheimer’s

Alzheimer’s disease is a progressive brain disorder that slowly destroys memory, thinking skills, and eventually the ability to carry out simple tasks. Here are the key points:

Main symptoms:
– Memory loss, especially about recent events
– Difficulty with familiar tasks
– Problems with language and communication
– Confusion about time and place
– Poor judgment
– Changes in mood and behavior

The disease occurs when protein deposits (called plaques and tangles) build up in the brain, causing brain cells to die. It most commonly affects people over 65, though early-onset cases can occur.

While there’s no cure yet, there are treatments that can help manage symptoms. Early diagnosis is important for better care and planning.

Symptoms of Alzheimer 

Early signs and symptoms:
– Memory loss that disrupts daily life, especially forgetting recently learned information
– Difficulty planning or solving problems
– Trouble completing familiar tasks
– Confusion with time or place
– Problems understanding visual images and spatial relationships
– New problems with words in speaking or writing
– Misplacing things and inability to retrace steps
– Decreased or poor judgment
– Withdrawal from work or social activities
– Changes in mood and personality

As the disease progresses, symptoms may include:
– Severe memory loss, including forgetting long-term memories
– Loss of ability to carry on conversations
– Difficulty with basic tasks like eating or using the bathroom
– Changes in physical abilities, including walking
– Behavioral changes like agitation or aggression

Causes of Alzheimer 

1. Primary Risk Factors:
– Age: The strongest risk factor; risk doubles every 5 years after age 65
– Genetics: Several genes are linked to increased risk
   – APOE-e4 gene variant significantly increases risk
   – Rare genetic mutations (APP, PSEN1, PSEN2) cause early-onset Alzheimer’s

2. Biological Mechanisms:
– Accumulation of beta-amyloid protein plaques between neurons
– Formation of tau protein tangles inside neurons
– Chronic inflammation in the brain
– Loss of neural connections and brain cell death
– Disrupted glucose metabolism in the brain

3. Modifiable Risk Factors:
– Cardiovascular health issues:
   – High blood pressure
   – High cholesterol
   – Diabetes
   – Obesity
– Head injuries and traumatic brain injury
– Poor sleep patterns
– Lack of physical exercise
– Limited cognitive stimulation
– Social isolation
– Smoking
– Heavy alcohol consumption

4. Protective Factors:
– Regular physical exercise
– Mediterranean-style diet
– Social engagement
– Mental stimulation
– Higher education levels
– Good sleep habits
– Management of cardiovascular risk factors

Benefits of Stem Cell Therapy for Alzheimer

Potential Benefits of Stem Cell Therapy for Alzheimer’s Disease:

1. Cell Replacement
– Can potentially replace damaged or dead neurons
– May help restore neural circuits and connections
– Could regenerate lost brain tissue

2. Neuroprotective Effects
– Stem cells release growth factors that protect existing neurons
– May reduce inflammation in the brain
– Can promote survival of remaining healthy cells

3. Therapeutic Mechanisms
– Potential to reduce amyloid-beta plaques and tau tangles
– May improve synaptic connectivity
– Could enhance brain plasticity

4. Disease-Modifying Potential
– Unlike current medications that only treat symptoms
– May slow or halt disease progression
– Could potentially reverse some damage

Current Limitations and Considerations:

1. Research Stage
– Most evidence comes from animal studies
– Clinical trials in humans are still in early phases
– Long-term effects not yet fully understood

2. Technical Challenges
– Getting stem cells to survive and integrate in the brain
– Ensuring cells develop into correct neural types
– Controlling cell growth and differentiation

3. Safety Concerns
– Risk of immune rejection
– Potential tumor formation
– Possible unwanted cell migration

4. Practical Considerations
– Treatment accessibility and cost
– Need for specialized medical facilities
– Timing of intervention may be critical

For international patients, Dr Stem Cell Therapy offers services such as medical visa processing, immigration services, accommodation, and post-treatment care. To get in touch with them, you can contact their international patient department at +91-880-2029988 or Indian patient department at +91-880-2029988.